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临床试验/NCT07827924
NCT07827924尚未招募不适用

DEONCAi 3-1: Can Large Language Models Support Shared Decision-Making and Informed Intentions in the Field: An Online Experiment Comparing Them to a Standard Model and to an Evidence-Based Decision Aid

Harding Center for Risk Literacy0 个研究点目标入组 330 人开始时间: 2026年9月15日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
330
主要终点
Patient-Reported Quality of Shared Decision-Making

研究概览

简要总结

This study investigates a novel, agentic Large Language Model (LLM) architecture designed to facilitate Shared Decision-Making (SDM) in healthcare. While patients increasingly use standard LLMs for health information, these models often struggle with multi-turn conversations and fail to adapt to varying reading levels, disadvantaging vulnerable groups. By utilizing an agentic state-machine, this project aims to overcome common LLM deficits-such as context loss and uncritical agreement-to ensure clinically accurate, participatory patient conversations. The study evaluates whether this architecture improves informed decision-making compared to standard LLMs, particularly for patients with low health literacy.

详细描述

Background & Current State of Research Shared Decision-Making is widely recognized as the gold standard of patient-centered care. However, its successful implementation in clinical practice is frequently hindered by systemic time and budget constraints. Consequently, patients are increasingly turning to Large Language Models to independently access health information and navigate their medical options.

The Problem: Limitations of Standard LLMs Recent studies indicate that using standard LLMs can digitally reproduce existing health inequalities and participation gaps. These models struggle to adapt to different reading levels without a significant loss in quality. While highly developed prompting techniques can enhance clinical accuracy, the results remain highly variable depending on the specific model and technique used.

A central deficit becomes apparent in multi-turn interactions, which are essential for a natural SDM workflow. In these prolonged conversations, standard LLMs tend to exhibit "context rot," leading to a sharp decline in accuracy as the dialogue progresses. This issue is further exacerbated by model sycophancy (an uncritical tendency to agree with the user) and completion eagerness (a tendency to prematurely conclude the conversation). Because current LLMs often fail to meet evidence-based reporting standards and lack systematic validation of user comprehension, the burden of fact-checking remains entirely on the user. This dynamic significantly disadvantages vulnerable groups, particularly those with lower health literacy.

Project Objectives and Research Questions

This project proposes a technical and clinical solution to these challenges through the following core research questions:

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Health Services Research
盲法
None

入排标准

年龄范围
40 Years 至 70 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Biological sex: Female.
  • Age: 40 to 70 years old.
  • Country of residence: United States (US) or United Kingdom (UK).
  • Language: Native English speaker (English as first language).
  • Registered and verified user on the academic research platform Prolific.
  • Able to read, understand, and provide informed consent digitally.

排除标准

  • Individuals who do not meet the automated pre-screening criteria on the Prolific platform.
  • Inability to use or access a computer, smartphone, or internet browser required to complete the digital study.
  • Note: Quotas will be enforced during recruitment to ensure a 50/50 stratified split between participants with and without university entrance qualifications to guarantee variance in educational backgrounds. Once a quota is filled, further participants matching that educational profile will be excluded.

研究组 & 干预措施

Shared Decision Making Chatbot

Experimental

Participants will engage in a multi-turn, AI-assisted consultation about mammography screening. They will interact with a newly developed agentic Large Language Model architecture that uses an integrated state-machine designed to actively guide the Shared Decision-Making process, adapt to the user's reading level, and prevent context loss.

干预措施: Agentic LLM Chatbot (Behavioral)

Standard Chatbot

Active Comparator

Participants will engage in a conversation about mammography screening using a standard, usual care Large Language Model (Mistral Large). This model represents the current consumer standard for AI health queries and lacks the specialized agentic state-machine and SDM workflow guidance.

干预措施: Usual Care LLM Chatbot (Behavioral)

Information brochure

Active Comparator

Participants will receive and read the standard informational patient brochure on mammography screening published by the German Institute for Quality and Efficiency in Health Care (IQWiG). This represents the current standard of care for patient information.

干预措施: IQWiG Standard Brochure (Behavioral)

结局指标

主要结局

Patient-Reported Quality of Shared Decision-Making

时间窗: Day 1

Assessed using the 9-item Shared Decision Making Questionnaire (SDM-Q-9). This validated instrument measures the patient's perceived involvement in the medical decision-making process. The questionnaire consists of 9 items, each rated on a 6-point scale ranging from 0 ("completely disagree") to 5 ("completely agree"). The raw scores are summed and multiplied by 20/9 to yield a total score ranging from 0 to 100. Higher scores indicate a higher perceived quality and greater patient involvement in shared decision-making.

次要结局

  • Multidimensional Informed Decision-Making(Day 1)
  • Subjective Decisional Conflict(Day 1)
  • Medical Accuracy and Safety of Generated Information(Day 1)

研究者

发起方
Harding Center for Risk Literacy
申办方类型
Other
责任方
Principal Investigator
主要研究者

Felix G. Rebitschek

Head of Research and CEO

Harding Center for Risk Literacy

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