Serum Irisin Levels in Myocardial Infraction and Following Percutaneous Coronary Intevention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 116
- 试验地点
- 2
- 主要终点
- changes from baseline in serum irisin measured by ELISA
研究概览
简要总结
The investigators aim to evaluate circulating irisin levels alterations in patients with acute myocardial infraction and in patients with coronary artery disease subjected to percutaneous coronary intervention.
详细描述
Irisin is a newly discovered myokine induced in exercise. There is evidence that cardiac muscle produces more irisin than skeletal muscle in response to exercise. Furthermore, irisin has been associated with isoproterenol-induced myocardial infarction (MI) in rats while it has been reported to decrease after acute myocardial infarction in humans.
The investigators aim 1) to investigate circulating irisin levels in patients at the time of acute myocardial infarction and after reprefusion [primary percutaneous coronary intervention (PCI)] 2) to compare irisin' s diagnostic and prognostic value and specificity value in myocardial infarction with known markers of cardiac injury such as creatine kinase-MB isoenzyme (CK-MB) and troponin 3) to evaluate irisin as an early necrosis biomarker 4) To evaluate irisin's sensitivity as a biomarker to detect minor myocardial necrosis after elective percutaneous coronary intervention
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute myocardial infraction (MI) or with coronary artery disease without myocardial infraction who need percutaneous coronary intervention
排除标准
- •age < 20 years old
- •diseases or medications that could affect cardiac muscle or skeletal muscle metabolism
- •musculoskeletal injury of surgery 6 months prior to recruitment
- •severe liver or kidney disease (creatinine clearance < 60ml/min/1.73m2) or liver or kidney transplantation
结局指标
主要结局
changes from baseline in serum irisin measured by ELISA
时间窗: baseline and 6 hours or 24 hours
次要结局
- changes from baseline in serum Activin A(baseline and 6 hours or 24 hours)
- changes from baseline in serum creatine kinase-MB isoenzyme(baseline and 6 hours or 24 hours)
- changes from baseline in serum follistatin(baseline and 6 hours or 24 hours)
- changes from baseline in serum Activin B(baseline and 6 hours or 24 hours)
- changes from baseline in serum pico pregnancy-associated plasma protein A (PAPP-A)(baseline and 6 hours or 24 hours)
- changes from baseline in serum creatine kinase(baseline and 6 hours or 24 hours)
- changes from baseline in serum follistatin-like protein 3 (FSTL-3)(baseline and 6 hours or 24 hours)
- changes from baseline in serum insulin growth factor 1 (IGF1)(baseline and 6 hours or 24 hours)
- changes from baseline in serum insulin growth factor binding protein 3 (IGFBP3)(baseline and 6 hours or 24 hours)
- changes from baseline in troponin(baseline and 6 hours or 24 hours)
- changes from baseline in serum lactate dehydrogenase(baseline and 6 hours or 24 hours)
- changes from baseline in serum insulin growth factor binding protein 4 (IGFBP4)(baseline and 6 hours or 24 hours)
研究者
Athanasios D. Anastasilakis
Consultant of Endocrinology
424 General Military Hospital