The Effect of Exenatide on Fasting Bile Acids in Newly Diagnosed Type 2 Diabetes Mellitus Patients, a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Plasma total bile acids in fasting state
研究概览
简要总结
Newly diagnosed T2DM participants without hypoglycemic drugs intake were retrospective analyzed. Plasma total bile acids in fasting state (FTBAs) and other parameters were compared before and after exenatide treatment and correlation analysis between changes of FTBAs and glycemic parameters.
详细描述
Newly diagnosed T2DM participants without hypoglycemic drugs intake were retrospective analyzed. Plasma total bile acids in fasting state (FTBAs) and other parameters were tested at baseline. Then exenatide were applied to the T2DM participants for 12 weeks. FTBAs and glycemic parameters were measured again after exenatide treatment, and correlation analysis between changes of FTBAs and glycemic parameters were conducted to investigate the role of BAs in the glycemic control effect of exenatide.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed T2DM patients
排除标准
- •History of hepatobiliary or pancreatic diseases
- •History of anti-diabetic drugs intake
- •Change of anti-dyslipidemia therapy regimen
- •Estimated glomerular filtration rate less than 60 mL/min/1.73 m^2
- •Pregnancy
研究组 & 干预措施
newly diagnosed T2DM participants
newly diagnosed T2DM participants without anti-diabetic drugs intake
干预措施: Exenatide treatment (Drug)
结局指标
主要结局
Plasma total bile acids in fasting state
时间窗: 12 weeks
reported in μmol/L
次要结局
- fasting plasma glucose(12 weeks)
- Glycated hemoglobin A1c(12 weeks)
- C-peptide(12 weeks)
- Fasting serum insulin(12 weeks)
- Body mess index(12 weeks)
研究者
Lihong Liu
professor
Beijing Chao Yang Hospital