Genetic Variants and Non-genetic Variables Associated With Postoperative Nausea and Vomiting (PONV)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,778
- 试验地点
- 1
- 主要终点
- Association study: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV
研究概览
简要总结
Prospective observational study to analyse the association of non-genetic variables as well as genetic variants of candidate genes with the incidence of postoperative nausea and vomiting (PONV).
详细描述
Background
Surgery and anesthesia are related to unwanted adverse events, side effects and postoperative discomfort. Postoperative nausea and vomiting are frequent and the question arises which patient is at specific risk for these sequelae. Some predisposing factors for PONV are well described, e.g. female sex, non-smoking status and postoperative opioids. Some drugs used for anesthesia as well as surgery related variables might induce PONV.
In this prospective association study patient related variables, surgical and anesthesia related variables as well as genetic variants of several candidate genes will be investigated in a well-described patient cohort presenting for scheduled surgery.
Objective
The aim of this study is to investigate a possible association of non-genetic variables and genetic variants with PONV.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years and older
- •Written informed consent
- •Elective surgery
- •Exclusion Criteria
- •No written informed consent
- •Cognitive impairment
排除标准
- 未提供
结局指标
主要结局
Association study: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV
时间窗: perioperative period up to 48 hours after surgery
PONV composite outcome measured by episodes of vomiting and nausea + need for antiemetic treatment + results of a patient reported outcome questionnaire. Patients with no PONV are compared to those with intermediate and severe PONV. Bariatric patients will not be included in this analysis.
次要结局
- Sex specific association analysis: Severity of PONV associated with genetic and non-genetic variables in males and females(perioperative period up to 48 hours after surgery)
- Association study in patients undergoing bariatric surgery: genetic and non-genetic variables associated with No PONV, Intermediate PONV and Severe PONV(perioperative period up to 48 hours after surgery)