A phase I study of weekly nab-Paclitaxel/Carboplatin with concurrent thoracic radiotherapy in elderly patients with unresectable locally advanced non-small cell lung cancer - A phase I study of weekly nab-Paclitaxel/Carboplatin with concurrent thoracic radiotherapy in elderly patients with unresectable locally advanced non-small cell lung cancer

Shizuoka cancer center0 个研究点目标入组 19 人开始时间: 2014年8月12日最近更新: 2023年10月17日

适应症

试验速览

阶段: 1 期
状态: 已完成
发起方: Shizuoka cancer center
入组人数: 19

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

Brief summary: Weekly nab-paclitaxel plus carboplatin combined with concurrent thoracic radiotherapy is associated with a high treatment completion rate and exhibits promising safety and efficacy in elderly patients with locally advanced NSCLC. Based on these results, a randomized phase III study of chemoradiotherapy for elderly patients with locally advanced NSCLC comparing weekly nab-paclitaxel plus carboplatin with daily carboplatin (JCOG1914) is currently enrolling.

研究设计

研究类型: Interventional

入排标准

年龄范围: 75years-old 至 ot applicable（—）
性别: All

入选标准

未提供

排除标准

•1)Active double cancer 2)History of severe infections or complications 3)HBs antigen positive 4)History of thoracic radiotherapy 5)Radiographically (chest CT image) confirmed interstitial pneumonitis or pulmonary fibrosis 6)Severe emphysema, chronic bronchitis, asthma 7)History of drug-induced pneumonia or severe drug allergies 8)Uncontrolled diabetes despite continuing treatment of insulin 9)Unstable angina, cardiac infarction within 6 months before enrollment 10)Obvious abnormality of the electrocardiogram 11)Grade 2 or higher peripheral neuropathy 12)A fever of over 38 degrees 13)Continuous systemic administration of steroid or immunosuppressant 14)Patients with severe mental illness 15)Unsuitable patients judged by the attending physician

研究者

发起方

Shizuoka cancer center

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不适用

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