RBR-5k7pnr尚未招募未知
Evaluation of the clinical and epidemiological profile of Tuberculous Spondylodiscitis in a quaternary hospital in the city of São Paulo. - : Evaluation of the clinical and epidemiological profile of Tuberculous Spondylodiscite in a quaternary hospital in the city of São Paulo
Irmandade da Santa Casa de Misericórida de São Paulo0 个研究点开始时间: 2019年1月11日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1D 至 100Y（—）
入选标准
- •Both genders; age: 1 day of life up to 100 years; diagnosis of tuberculosis of the spine. Diagnosis will be defined by: isolation of the etiological agent or by clinical and radiographic criteria characteristic of tuberculosis vertebral involvement and or pathological examination compatible with tuberculosis and / or positive therapeutic test. Isolation of the agent will be considered the presence of BAAR by the Ziehl-Neelsen method, molecular rapid test (real-time PCR) and culture for mycobacteria. The radiographic findings are visualized in radiographs of the spine according to the affected level, in the posteroanterior and profile incidences, with the following findings: aneurysmal abscess, sacral lesions, disc space reduction, vertebral collapse, kyphosis, calcification. The findings found on computed tomography are a decrease in the height of the vertebral body, osteolysis in the terminal plates of the vertebral bodies adjacent to the disc, pre-vertebral abscess, paravertebral abscess. Magnetic resonance imaging findings are hyposignal of the affected disc in weighted images at t1; hypersignal of the disc and the vertebral plateaus adjacent to the disc in t2-weighted images; epidural involvement; paraespinal abscess with a smooth abscess wall. Clinical Criteria: Indolent chronic infection associated with leukocytosis and changes in inflammatory tests, CRP and HSV, associated or not with the positive tuberculin test; Anatomopathological examination: The presence of epithelioid macrophage proliferation constituting confluent granulomas with presence of giant Langerhans cells with central foci of caseous necrosis and surrounding lymphocytic infiltrate was considered a characteristic of TB, with positive BAAR using the Ziehl-Neelsen method . The samples were submitted to routine methods for optical microscopy: 10% formaldehyde fixation, paraffin blocks cut into a 3 micron thick microtome and stained by hematoxylin-eosin (HE), Grocott (for fungi research) and Ziehl-Neelsen (for the BAAR survey). The biopsies were processed according to routine of the laboratory of Pathological Anatomy;
排除标准
- •Do not meet the criteria for definition of tuberculo spondylodiscites case; incomplete Medical Record; incomplete image checks
研究者
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