To compare efficacy of addition of dexmedetomidine or placebo to ropivacaine scalp block to attenuate the hemodynamic response to skull pin placement in neurosurgical procedures
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at different time points following skull pin placement .
研究概览
简要总结
This will be a prospective randomised double blind placebo control study In this study 60 patients belonging to ASA physical status grading 1 and 2 will be allocated into two groups each group containing 30 patients In group D patients will be recieving 25ml of 0.5 percent ropivacaine with dexmedetomidine 1 microgram per kg and this solution will be made 30ml In group R patients will be recieving 25 ml of 0.5 percent ropivacaine with normal saline and solution will be made 30 ml Heart rate systolic blood pressure diastolic blood pressure and mean arterial pressure are mnoted before skull pin fixation 1 3 5 and 10 min after skull pin fixation Results will be coded after study
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of either sex Patients aged 18 to 65 years American Society of Anesthesiologists physical status grade I and II Patients scheduled for elective neurosurgical procedures under general anesthesia with tracheal intubation.
排除标准
- •Patients with uncontrolled hypertension Patients with preoperative bradycardia, ischemic heart disease, cardiac arrhythmias Patients with severe hepatic and renal disease Patients with past history of craniotomy Patients allergic to study drugs Patients on alpha blockers treatment preoperatively Patient refusal Patient unable to give consent Pregnant women and lactating mothers.
结局指标
主要结局
Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at different time points following skull pin placement .
时间窗: Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure are measured at 1 3 5 10 minutes following skull pin placement
次要结局
- 2.Number of episodes of hypertension, hypotension, bradycardia and tachycardia(during study period.)