NCT02522338已完成4 期
Measurement of Glomerular Filtration Rate (GFR) in HIV Patients: Single-center Study Comparing the Accuracy of Estimators of GFR Versus Iohexol Plasma Clearance
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Patient with a predictive performance range -30% to +30%
研究概览
简要总结
Cystatin C, a protease inhibitor produced by most nucleated cells, is freely filtered by the kidneys, and its plasma assay reflects the GFR.
Compare, in HIV patients, the predictive performance of 11 formula to estimate GFR based on assay plasma cystatin C with that of the MDRD formulas.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients infected with HIV, and included in the cohort NADIS
排除标准
- •Patient with a known allergy
- •Patients treated with metformin
- •Patients with severe hepatic impairment defined as a TP spontaneously below 50%
- •Patients with a history of dysthyroidism
- •Patient with active neoplasia other than skin cancer
- •Degradation recent (not older than 3 months) in renal function defined as the deterioration of GFR over 25%.
- •Estimated GFR less than 15 mL/min/1, 73m2
- •Pregnant or lactating
- •Subjects under the protection of justice
研究组 & 干预措施
iohexol plasma clearance
Other
patients had received iohexol for measuring GFR
干预措施: iohexol (Drug)
结局指标
主要结局
Patient with a predictive performance range -30% to +30%
时间窗: day 0
for each estimator :predictive performance calculated by \[(DFG estimé\* - DFG mesuré par iohexol\*\*)/DFG mesuré par iohexol\]X100
次要结局
未报告次要终点
研究者
研究点 (1)
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