Double-blind, Placebo-controlled, Randomized Study: Oxytocin and OXTR-genotypes Influence Behavioral and Neural Social Reactions
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 153
- 试验地点
- 1
- 主要终点
- neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli
研究概览
简要总结
The purpose of this study is to determine whether oxytocin influences memory of social stimuli and reaction to social stimuli. Furthermore the investigators explore the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli.
详细描述
The prevailing view of OXT as a key facilitator of prosocial behaviors has been highly influenced by a plethora of studies in healthy volunteers, which demonstrated increased interpersonal trust, generosity, social learning/empathy and positively biased social stimulus processing as a result of OXT treatment. However, this interpretation is challenged by observations that OXT also promotes envy and schadenfreude (gloating), ethno-centrism (including prejudice, xenophobia, and racial bias), and defensive aggression towards outsiders.We investigate the neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli. Tthe oxytocin effect on personal space is questioned. Additionally the effect of OXTR polymorphism regarding behavioral and neural response is explored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteers
排除标准
- •Current or past psychiatric disease
- •Current or past physical illness
- •Psychoactive medication
- •Tobacco smokers
- •MRI contraindication
研究组 & 干预措施
Oxytocin
one application of 24 IU oxytocin per volunteer
干预措施: Oxytocin (Drug)
Placebo
sodium chloride solution, intranasal application, 3 puffs per nostril one application per volunteer
干预措施: Oxytocin (Drug)
结局指标
主要结局
neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli
时间窗: two years
MRI data are analyzed using SPM8 (Wellcome Trust Centre for Neuroimaging, London, UK). In the first level analysis the following conditions are modeled: 'neutral: subsequently remembered', 'neutral: subsequently forgotten', 'aversive: subsequently remembered', and 'aversive: subsequently forgotten'.
次要结局
- the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli(two years)
- The oxytocin effect on social behavior e.g. personal space is questioned(two years)
研究者
Rene Hurlemann
MSc MD PhD
University Hospital, Bonn