NCT00384540已完成不适用
Allograft Vasculopathy After Heart Transplantation : Diagnostic Interest of Dobutamine Stress Echocardiography and Brain Natriuretic Peptide Coupling
University Hospital, Strasbourg, France2 个研究点 分布在 1 个国家目标入组 53 人开始时间: 2006年9月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 53
- 试验地点
- 2
- 主要终点
- Cardiovascular events vs Dobutamine stress echocardiography each 2 years
研究概览
简要总结
Primary purpose :To early detect cardiac allograft vasculopathy and to identify patients with high risk of cardiac events, by coupling the analysis of the kinetics of the brain natriuretic peptide ( BNP) with that of the left ventricle (LV) during a dobutamine stress echocardiography.
Hypothesis : Plasma BNP elevation and abnormalities of LV kinetic during the ESD, will be associated with the presence of allograft vasculopathy and the arisen of cardiovascular events.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heart transplant recipients
排除标准
- •No respect of inclusion criteria
- •Pregnancy
- •Severe renal failure (creatinin clearance < or equal to 30 ml/min)
- •Dobutamine stress echocardiography contraindication
研究组 & 干预措施
Cardiovascular events vs Dobutamine stress echocardiography
Other
干预措施: Dobutamine stress echocardiography, coronarography, brachial arterial echography (Procedure)
结局指标
主要结局
Cardiovascular events vs Dobutamine stress echocardiography each 2 years
时间窗: 5 years
次要结局
- Flow mediated humeral dilatation each 2 years(5 years)
研究者
研究点 (2)
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