Glucose and Lipid Metabolism in Adolescents
试验速览
- 阶段
- 不适用
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis
研究概览
简要总结
A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.
详细描述
Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 13 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No medication
- •Sedentary
- •No first degree relative with diabetes,
- •BMI >30 or <25 kg/m2.
排除标准
- •Any medication including birth control pills
- •Performing more than >45 min of moderate to light physical activity/week
- •Chronic illness
结局指标
主要结局
Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis
时间窗: In response to a 12 wk exercise program.
次要结局
- Lipolysis, blood lipids, adiponectin, leptin and CRP(In response to a 12 wk exercise program)