Effects of a 12-week Combined Exercise Program on Acylated and Desacyl Ghrelin, and Ghrelin O Acyl Transferase in Obese Adolescent Girls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- desacylated ghrelin
研究概览
简要总结
This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.
详细描述
Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 18 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •girls between 16 and 18 years
- •being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years.
- •After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school.
排除标准
- •participation in any weight-management programme in the past 6 months
- •engagement in other exercise programs except for regular physical education at school
- •amenorrhea for consecutive 2 months or more
- •being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments
- •taking any medication or supplements for weight control
结局指标
主要结局
desacylated ghrelin
时间窗: Change from concentrations of baseline desacylated ghrelin at 12 weeks
Changes in concentrations of desacylated ghrelin during 12 weeks
body fat percent
时间窗: Change from baseline body fat percent at 12 weeks
Changes in body fat percent during 12 weeks
acylated ghrelin
时间窗: Change from concentrations of baseline acylated ghrelin at 12 weeks
Changes in concentrations of acylated ghrelin during 12 weeks
次要结局
- ghrelin O acyl transferase(Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks)
研究者
Sang Yeoup Lee
Professor
Pusan National University Yangsan Hospital