NCT07705724尚未招募不适用
Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, And Cognition in Post-Menopausal Women
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Integrated Muscle Protein Synthesis (iMPS)
研究概览
简要总结
The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged 50 to 65 years
- •Body mass index ≥25 to <40 kg/m2 or body fat ≥36%
- •Able to provide informed consent
- •Absence of menstruation for ≥12 months without the use of hormonal contraceptives, or one of the following:
- •Another medical cause of menopause e.g., history of bilateral oophorectomy
- •Clinician-confirmed menopausal status for those with hysterectomy and retained/unknown ovaries
- •Partial/total hysterectomy ≥12 months ago and current age ≥55 years
排除标准
- •Allergy or intolerance to dairy products (other allergies or intolerances may be excluded if they are not compatible with the study meals and how they are prepared)
- •Conditions, medications, or recent changes in medications that cause participants to be metabolically unstable (e.g., renal, cardiovascular, thyroid, polycystic ovary syndrome, type-1 and type-2 diabetes)
- •Gastric bypass/bariatric surgery in the previous 5 years
- •Pregnancy or nursing in the prior 12 months
- •Weight loss or gain >5 kg in the last two months
- •Unable or unwilling to suspend use of blood thinning medications and non-steroidal anti-inflammatory drugs for the duration of the study
- •Unwilling to abstain from vigorous exercise for the study period
- •Does not or will not eat all foods on the standardized diet (e.g., allergies, intolerances, or taste preferences)
- •Participants may be excluded at the Principal Investigator's discretion if their health or body composition is not compatible with the required study procedures
研究组 & 干预措施
Skimmed Milk Greek Yogurt
Active Comparator
Participants will consume two servings per day of skimmed milk Greek yogurt.
干预措施: Skimmed vs Whole Milk Greek Yogurt (Other)
Whole Milk Greek Yogurt
Active Comparator
Participants will consume two servings per day of whole milk Greek yogurt.
干预措施: Skimmed vs Whole Milk Greek Yogurt (Other)
结局指标
主要结局
Integrated Muscle Protein Synthesis (iMPS)
时间窗: 1 week
Integrated muscle protein synthesis expressed as the fractional synthetic rate (%/day).
次要结局
- Glucose Homeostasis(1 week)
研究者
研究点 (1)
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