The Effect of Carbonic Anhydrase Inhibitors on the Pulmonary System Response to Muscle Fatigue.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol
研究概览
简要总结
The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age: 18-40 years.
- •Regularly physically active
排除标准
- •current or ex-smokers
- •pulmonary function <80% of predicted
- •esophageal tumour or ulcer
- •have had recent (<6 months) musculoskeletal injury or any surgery to the lower leg
- •have contraindications to carbonic anhydrase inhibitors (eg. severe or absolute glaucoma, adrenocortical insufficiency, hepatic insufficiency, renal insufficiency, sulfa allergy or an electrolyte imbalance such as hyperchloremic acidosis)
- •are obese (BMI >30 Kg/m2)
- •taking diuretics, blood thinners, or anti-platelet drugs.
研究组 & 干预措施
Acetazolamide
Participants will be dosed 250mg acetazolamide (p.o.) three times per day for two days prior to and a single dose on the morning of the experimental day.
干预措施: Acetazolamide (Drug)
Methazolamide
Participants will be dosed 100mg Methazolamide (p.o.) two times per day separated by a placebo dose for two days prior to and a single dose on the morning of the experimental day. The placebo dose is used to match the timing and number of pills taken between all arms of the study.
干预措施: Methazolamide (Drug)
Placebo
Participants will take three placebo pills per day for two days prior to and a single dose on the morning of the experimental day.
干预措施: Placebo (Other)
结局指标
主要结局
Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol
时间窗: Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study
Change in trans-diaphragmatic pressure generation to supramaximal phrenic nerve stimulation following inspiratory threshold loading.
时间窗: Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study
次要结局
- Contraction time and half-relaxation time(Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol)
- Maximal inspiratory pressure maneuvers(Baseline and immediately following loading protocol)
- Maximal Voluntary Contraction of the Plantar Flexor Muscle Group(Baseline and immediately following the loading protocol)
研究者
Glen Foster
Assistant Professor
University of British Columbia