NCT00345150已完成1 期
Phase 1 Study of the Effects of Systemic Nitric Oxide Inhibition With Ng-Monomethyl-L-Arginine on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls
Regional Hospital Holstebro0 个研究点目标入组 30 人开始时间: 2006年6月27日最近更新:
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相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion in patients with essential hypertension. The results are compared with a group of healthy subjects.
详细描述
The study investigates the effects of Ng-monomethyl-L-arginine (L-NMMA) on:
- renal hemodynamics (renal plasma flow and glomerular filtration rate)
- renal sodium excretion
- lithium clearance and fractional lithium excretion
- plasma levels of vasoactive hormones
- blood pressure and heart rate
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Essential hypertension (blood pressure > 140/90) with no signs of secondary hypertension
- •P-creatinine < 200 µmol/L
排除标准
- •Anamnestic or clinical signs of heart disease, renal disease, liver disease, neoplastic disease, anemia or cerebro-vascular insult
- •Medication except antihypertensives
- •Drug or alcohol abuse
- •Pregnancy
研究者
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