Predictors of Early Neurological Outcome in Children With Encephalitis: A Prospective Study From Assiut University Children Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 88
- 主要终点
- Functional neurological outcome at discharge
研究概览
简要总结
This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University Children Hospital.
详细描述
Encephalitis in children carries a high risk of neurological sequelae. This observational study will include children aged 1 month to 12 years with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.
Baseline clinical, laboratory, neuroimaging, and EEG findings will be recorded. Early neurological outcome will be assessed at hospital discharge using the pediatric modified Rankin Scale (mRS).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 1 month to 12 years
- •Possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition
- •Written informed consent from parents or legal guardians
排除标准
- •Pre-existing severe neurodisability pediatric modified Rankin Scale greater than or equal to 3 before the index illness
- •Primary diagnosis of traumatic brain injury or cerebral malaria
- •Known inborn error of metabolism or neurodegenerative disorder prior to the encephalitis episode
- •Absence of documented neurologic outcome assessment
研究组 & 干预措施
Single cohort: Children with encephalitis
Children aged 1 month to 12 years with possible or probable encephalitis who will be assessed for early neurological outcome at hospital discharge using the pediatric modified Rankin Scale.
结局指标
主要结局
Functional neurological outcome at discharge
时间窗: Up to 30 days
Score on the pediatric modified Rankin Scale at hospital discharge. The scale ranges from 0 (no symptoms) to 6 (death), with higher scores indicating worse functional outcome
次要结局
- Duration of hospital stay(Up to 30 days)
- Need for intensive care unit admission(Up to 30 days)
- Need for nasogastric tube feeding at discharge(Up to 30 days)
- Nosocomial infections(Up to 30 days)
研究者
Rania Ahmed Hussein
Resident Physician
Assiut University