Effects of Genotypes on Interferon Signaling in Chronic Hepatitis C
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Prognostic criteria for sensitivity of Chronic Hepatitis C patients to interferon alpha treatment
研究概览
简要总结
The objective of this pilot project is to investigate the prognostic criteria for sensitivity of Chronic Hepatitis C (CHC) Genotype 1, patients to IFNa treatment. Signal transduction in peripheral blood mononuclear cell (PBMC) of control groups will be compared with that of CHC patients. For this study, 20 patients with Hepatitis C virus (HCV) infection who are to undergo standard antiviral therapy and 10 healthy donors (significant others of the HCV subject) will be enrolled. Signal transduction will be studied in peripheral blood of CHC subjects before the treatment, after 1 and 3 months of treatment, and 4-6 months following the completion of treatment.
详细描述
In addition, the mechanism of non-responsiveness of HCV patients to IFNa will be studied. For this purpose, formation of complexes between STAT1 and its negative regulator, PIAS1 (immunoprecipitation, Western blot) will be examined. In comparing subjects on standard therapy vs the addition of betaine, (under separate studies) we will assess whether the formation of STAT1-PIAS1 complexes is due to impaired methylation on STAT1 on arginine residues which may be over come by the addition of betaine.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Prognostic criteria for sensitivity of Chronic Hepatitis C patients to interferon alpha treatment
时间窗: 3 years
To investigate the prognostic criteria for sensitivity of Chronic Hepatitis C patients to interferon alpha treatment
次要结局
- Effects of antiviral treatment on interferon gene signaling in peripheral blood mononuclear cells(3 years)