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临床试验/NCT00975364
NCT00975364已完成不适用

Pilot Study to Investigate Relationship Between Common Folate Gene Polymorphisms, Folate Status and Cellular Folate Speciation

Quadram Institute Bioscience1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2009年2月最近更新:
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适应症

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
1
主要终点
Relationship between MTHFR TT, CT and CC genotype and red cell folate species
研究概览入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.

详细描述

The main questions to be addressed in this pilot study are:

  1. what is the type of folate in red blood cells in individuals with different methylterahydrofolate reductase (MTHFR) genotypes
  2. what is the relationship between other folate metabolism-related gene single nucleotide polymorphisms and type (species) of folate found in red blood cells
  3. what is the relationship between folate and other B vitamin status, genotype and folate species
  4. is there a relationship between serum ferritin status and folate metabolism

Whole blood will be taken from apparently healthy male and female volunteers, aged 18-65, which will be used to determine genotype for various folate metabolism-related genes. Furthermore, the type of folate present on the red blood cells will be assessed, and folate, vitamin B12, riboflavin and serum ferritin status determined.

研究设计

研究类型
Observational

入排标准

年龄范围
18 Years 至 65 Years（Adult, Older Adult）
性别
All
接受健康志愿者
是

入选标准

  • •Aged 18-65
  • •Males and females
  • •Body Mass Index greater than 19.5 and less than 40
  • •Smokers and non-smokers

排除标准

  • •Pregnancy or been pregnant in last 12 months
  • •Parallel participation in another research project if total amount of blood from combined studies is greater than 470ml
  • •Participation in another research project where blood samples were taken within the past 4 months, unless total blood volume does not exceed 470ml
  • •Any person related to or living with a member of the study team
  • •Has donated or intends to donate blood within 16 weeks (prior to or after) the study

结局指标

主要结局

Relationship between MTHFR TT, CT and CC genotype and red cell folate species

时间窗: July 2010

次要结局

  • Relationship between other folate metabolism related genes and red cell folate species(July 2010)
  • Relationship between folate, B12, riboflavin and ferritin status and red cell folate species(December 2010)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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