NCT01571609已完成不适用
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- insulin secretion
研究概览
简要总结
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-70 years of age
- •Member of Biobank Vejle
排除标准
- •Diabetes mellitus
- •Severe illness
研究组 & 干预措施
Carriers
Experimental
干预措施: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer (Other)
Non-carriers
Experimental
干预措施: first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer (Other)
结局指标
主要结局
insulin secretion
时间窗: 10 minutes
Estimation of first phase insulin secretion
次要结局
- Insulin resistance(60 minutes)
- body composition(60 minutes)
- atherosclerosis(30 minutes)
- biochemical blood profiling(at baseline)
- Blood pressure(24 hours)
- Indirect calorimetry(60 minutes)
- Insulin resistance(240 minutes)
研究者
研究点 (1)
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