Hypomagnesemia Associated With Proton-Pump Inhibitor Use
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 211,672
- 试验地点
- 1
- 主要终点
- Hypomagnesemia due to use with proton pump inhibitor
研究概览
简要总结
Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of hypomagnesemia. Our aim was to evaluate the likelihood that proton pump inhibitors contributed to severe hypomagnesemia in a retrospective cohort of patients admitted with severe hypomagenesemia. We also aimed to look for risk factors leading to development of hypomagnesemia amongst users of proton pump inhibitors
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 14 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted with hypomagnesemia (cases)
- •Patients prescribed with proton pump inhibitors (controls)
排除标准
- •Patients prescribed with less than three months duration of proton pump inhibitors (controls)
研究组 & 干预措施
Case
Patients admitted with hypomagnesemia are evaluated for proton pump inhibitor use and likelihood of hypomagnesemia due to proton pump inhibitor use
干预措施: proton pump inhibitor use (Drug)
Control
Patients on long-term proton pump inhibitor without documented hypomagnesemia
干预措施: proton pump inhibitor use (Drug)
结局指标
主要结局
Hypomagnesemia due to use with proton pump inhibitor
时间窗: 2013 to 2016
Number of patients with Hypomagnesemia related to use of proton pump inhibitor using Naranjo score
次要结局
- Risk factors for Hypomagnesemia(2013 to 2016)
- Hypocalcaemia(2013 to 2016)
- Hypokalemia(2013 to 2016)