Structural and Functional Brain Reorganization in Neuropathic Pain. Influences of the Loss of Sensitivity and the Atrophy Cortical on Activations Due to Stimulation Allodynic
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- gray matter rate
研究概览
简要总结
Neuropathic pain is a medical condition involving allodynia (painful perceptions in response to stimuli that normally are not) and spontaneous pain (occurring at rest, without stimulation).
This pain is secondary to nervous system injury affecting the sensory system. The lesion is either at the nerve endings of the spinal cord or brain. It induces a loss of sensitivity and reorganization of brain activity.
Previous studies in functional neuroimaging have focused on brain areas activated during allodynic stimuli compared to non-painful stimuli. The abnormalities have been reported, but it was not possible to conclude formally.
The objective of this study is to understand the brain dysfunction that induces allodynic pain considering the deafferentation of each patient and possible cortical losses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •with neuropathic pain
- •in the case of central lesions, the lesion must be unique and small
- •treatment not stable opioid for one week
- •consent signed
排除标准
- •severe psychiatric history
- •presence of an evolutive lesion, expansive, cancerous or tumorous underlying
- •patient needing of opioid therapy
- •contraindication at MRI scan
结局指标
主要结局
gray matter rate
时间窗: at baseline
gray matter rate measured with MRI scan
the deafferentation rate
时间窗: at baseline
the deafferentation rate measured with thermo-test
次要结局
- Analysis pain(at baseline)