The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- PCA Press Frequency 48h After Operation.
研究概览
简要总结
This study was conducted to explore whether the non-synonymous single-nucleotide polymorphisms in SCN9A gene can predict individual basal pain perception and postoperative pain intensity in the general population undergoing upper abdominal surgery. Methods: Patients receiving elective upper abdominal surgery under general anesthesia were recruited into this study. Genotyping of SCN9A was carried out by direct sequencing. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). The visual analog scale (VAS) was used for pain evaluation at rest during patient-controlled analgesia (PCA) treatment 0 h, 12 h ,24 h and 48h after operation. And the PCA press frequency and drug consumption were recorded.
详细描述
Patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 20-70 years
- •Receiving elective upper abdominal surgery
- •Anesthesiologists (ASA) physical status I or II
- •Received PCA administration
- •Agreed to participate the research
排除标准
- •History of chronic pain
- •Psychiatric diseases
- •Diabetes mellitus
- •Severe cardiovascular diseases
- •Kidney or liver diseases
- •Alcohol or drug abuse
- •Heavy smoker
- •Pregnancy or at lactation period
- •Refused PCA administration
- •Disagree to participate to the research
结局指标
主要结局
PCA Press Frequency 48h After Operation.
时间窗: 48 hours after the operation
Opioid Consumption Dose 48h After Operation.
时间窗: 48 hours after the operation
次要结局
- Preoperative Pressure Pain Threshold (PPT)(12 hours before the operation)
- The Visual Analog Scale 48h After Operation.(48 hours after the operation)
- Preoperative Pressure Pain Tolerance (PTO)(12 hours before the operation)
研究者
Xianwei Zhang
Clinical Professor
Huazhong University of Science and Technology