Sepsis Mortality in Hospitals: a Quality Indicator in Acute Care Settings
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Comparative Analysis of Plasma Bioelectrical Properties in Sepsis
研究概览
简要总结
Sepsis is one of the leading causes of hospital mortality, with a rate of approximately 20% (World Health Organization) among vulnerable patients admitted to high-intensity care units such as CCUs and inpatient wards. Currently, diagnostic criteria such as the Systemic Inflammatory Response Syndrome (SIRS) and the Sequential Organ Failure Assessment (SOFA) score, although widely used, lack sufficient specificity and accuracy. No established parameters are available for early and timely diagnosis. This study aims to address this gap by investigating the variability of blood plasma conductivity and dielectric constant using microwave probes previously validated for non-invasive glucose monitoring. The acquired data will be analyzed using the Anritsu VectorStar VNA to identify innovative and reliable parameters associated with the presence of severe infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Cardiology patients without documented infection (Control Group)
- •Patients with sepsis
- •Patients with nosocomial infection
- •Patients with myocarditis, endocarditis, or pericarditis
- •Ability to provide written informed consent
排除标准
- •Patients with severe or chronic medical conditions that may interfere with study results, such as autoimmune diseases, renal or hepatic failure
- •Patients taking medications that could affect the measured biophysical parameters, such as corticosteroids or immunosuppressants
- •Patients with cancer
- •Patients with diseases involving the immune system (e.g., lymphomas, leukemias)
- •Patients with congenital or acquired immunodeficiencies (e.g., HIV)
- •Patients who are unable to read and sign the informed consent form
结局指标
主要结局
Comparative Analysis of Plasma Bioelectrical Properties in Sepsis
时间窗: through study completion, an average of 10 days
differences in blood plasma conductivity and dielectric constant will be analyzed between patients with and without sepsis, using validated microwave probes and appropriate statistical methods.
次要结局
- Correlation Between Biophysical Parameters and Conventional Infection and Inflammation Biomarkers(through study completion, an average of 3 months)
研究者
Antonio Curcio
Professor
University of Calabria