jRCT1032240550招募中不适用
Evaluation of neuroplasticity and molecular profile of plasma exosomes after neurorehabilitation for Parkinson's disease
None0 个研究点目标入组 40 人开始时间: 2024年1月12日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 主要终点
- Neuroplasticity
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Single Arm Study
- 干预模型
- Single Assignment
- 主要目的
- Other
- 盲法
- Open(masking Not Used)
入排标准
- 年龄范围
- 20age 0month 0week old over 至 No limit（—）
- 性别
- All
入选标准
- •PD patients diagnosed by a neurologist based on the UK Parkinson's Disease Society Brain Bank
- •PD patients currently attending our outpatient clinic
- •Yahr severity level 3 or less
排除标准
- •Patients under 20 years of age
- •Patients with moderate or higher cognitive function (MMSE < 24)
- •Patients with contraindications for MRI due to pacemakers, metal in the body, or claustrophobia
- •Patients for whom aerobic exercise is deemed inappropriate due to unstable hypertension, diabetes, cerebrovascular disease, heart disease (ischemic heart disease, arrhythmia, heart failure, etc.), peripheral arterial occlusive disease, orthostatic hypotension, pulmonary disease, etc.
- •Patients with neurological or orthopedic diseases who cannot undergo rehabilitation using stretching or an exercise bike
- •Patients with mental disorders such as depression diagnosed by a psychiatrist, or those with significant mental symptoms
结局指标
主要结局
Neuroplasticity
Determined by comparing head MRI before and after neurorehabilitation
Molecular mechanisms related to neuroplasticity
Determined by integrated analysis of changes in blood exosome profiles
次要结局
- Neuroplasticity
- Blood exosome profile
- PD-related evaluation items
研究者
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