Median Effective Dose (ED50) of Esketamine Combined With Alfentanil for Children to Inhibit Body Movement During Laser Treatment for Facial Lesion
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- half effective dose of inhibition of body movement
研究概览
简要总结
There is limited research on the combined use of esketamine and alfentanil for anesthesia during facial laser treatment in pediatric patients, and the effective dosage of esketamine for inhibiting body movement remains unclear. We explore the effective dose of esketamine combined with alfentanil for the inhibition of body movement during facial laser treatment in pediatric patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Sequential
- 主要目的
- Other
- 盲法
- None
盲法说明
Esketamine will be prepared by an investigator who is not involved in anesthesia and outcome assessment. For all participants, esketamine will be diluted to the same volume.
入排标准
- 年龄范围
- 3 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age between 3 years and 12 years old
- •patients scheduled for laser treatment of facial lesion
排除标准
- •patients with airway infection during the last 1 month
- •patients with cardiac or pulmonary disorder
- •patients with hepatic or renal disfunction
- •patients with neurologic or psychiatric disorder
研究组 & 干预措施
esketamine
esketamine will be given intravenously
干预措施: Esketamine (Drug)
结局指标
主要结局
half effective dose of inhibition of body movement
时间窗: from injection of esketamine to start of laser treatment, in an average of 5 minutes
次要结局
- number of patients with agitation during awake(from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes)
- number of patients with dizzy during awake(from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes)
- satisfaction score of the parents to the anesthesia(from end of laser treatment to discharge from the outpatient unit, in an average of 60 minutes)
- number of patients with apnea during awake(from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes)
- number of patients with nausea and vomiting during awake(from end of injection of esketamine to 30 minutes after laser treatment, in an average of 60 minutes)
研究者
Zhihong LU
Associate professor
Air Force Military Medical University, China