Optic Nerve Sheath Diameter in Retrobulbar Ultrasound as a Surrogate Measure for Intracranial Pressure Before and After Non-invasive Strategies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Optic nerve sheet diameter
研究概览
简要总结
Measurement of the diameter of the sheath of the optic nerve in patients hospitalized in intensive care, with increased intracranial pressure (> 20mmHg) as a substitute measure for diagnosis and follow-up before and after different non-invasive strategies.
Three groups were created in which, through strategies already proven and non-invasive (mannitol, hypertonic solution 7.5% NaCl, reverse trendelenburg) to decrease the intracranial pressure, the optic nerve diameter measurement was performed and simultaneously the investigators monitored intracranial pressure through an intraventricular catheter continuously to determine if both correspond
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥ 18 years old) with traumatic or non-traumatic elevated ICP (defined as greater than 20 mm Hg for at least 10min)
- •Hospitalized in ICU
- •Patients with ICP continuous measurement through an intraventricular catheter
- •Respiratory rate maintained at 10-18 breaths/min to maintain the end tidal carbon dioxide partial pressure between 35 and 40 mmHg
- •Peak airway pressure <35 cmH2O
- •Positive end-expiratory pressure <5 cmH2O
排除标准
- •Patients who had undergone cranial decompression surgery
- •Patients with ocular pathology
- •Patients who had previously undergone eye surgery
结局指标
主要结局
Optic nerve sheet diameter
时间窗: immediately before administering the treatment according to the group and every 30 minutes after administering the treatment until 90 min.
The optic nerve sheet diameter in each eye was measured vertically and horizontally 3 mm behind the optic disc, with the two values averaged
次要结局
未报告次要终点
研究者
Aldo Saad Diab
Principal Investigator, anesthesiologist.
Hospital Dr. Miguel Pérez Carreño