The Susceptibility of Phenotypic Plasticity During Adversity and Prosperity in Infants With Visual Deprivation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change from baseline in visual acuity measured by Teller visual acuity cards
研究概览
简要总结
Phenotypic plasticity is the ability of individuals to change their phenotypic status when exposed to environmental variations. However, whether the plastic changes show differential susceptibility in adversity and prosperity is debated and the specific pattern of plasticity remains elusive.
Here the investigators address this question by tracking the phenotypes (functional, structural, physical, and attachment traits) in two groups of infants before and after visual deprivation: one group experienced a short duration of complete deprivation (extreme adversity) and the other group experienced a long durations of partial deprivation (watered-down adversity).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis with dense or non-dense nuclear congenital cataract
排除标准
- •no metabolic diseases, mental retardation or central nervous diseases
- •had no history of inherited diseases
研究组 & 干预措施
dense cataract group
干预措施: bilateral cataract removal surgery for dense cataract (Procedure)
non-dense nuclear cataract group
干预措施: bilateral cataract removal surgery for non-dense nuclear cataract (Procedure)
结局指标
主要结局
Change from baseline in visual acuity measured by Teller visual acuity cards
时间窗: 1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery
次要结局
- Change from baseline in refractive status measured by autorefractor and objective retinoscopy(1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery)
研究者
Haotian Lin
Ophthalmologist
Sun Yat-sen University