A non-inferiority, randomized, controlled trial comparing high flow nasal cannula to non-invasive ventilation in patients with acute cardiogenic pulmonary edema in emergency room - nil

AIIMS BHUBANESWAR0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年10月16日

试验速览

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•1.Patients of age 18 to 80years, presenting to Emergency department with acute dyspnea, with clinical, radiological and ultrasonography evidence of acute cardiogenic pulmonary edema.
•2.The patient must have substantial breathing difficulties that necessitate the use of non-invasive ventilation techniques to provide relief which is assessed by following criteria
•2.1 Respiratory rate(RR) >25 breaths/min with signs of respiratory distress such as, use of accessory muscles of respiration
•2.2 SpO2 <90% on room air,PaO2/FiO2 <200 with maximum oxygen supplementation by conventional methods.

•1.Patients needing immediate endotracheal intubation due to severe respiratory distress and inability to maintain adequate oxygenation(SpO2 <90% with oxygen supplementation)
•2.Patients with cardiac or respiratory arrest
•3.Patients with hemodynamic instability
•4.Patients with a low Glasgow Coma Scale score <10
•5.Patients having excessive respiratory secretions
•6.Agitated/Non-cooperative patients
•7.Patients associated with pulmonary diseases like AECOPD/pneumonia/interstitial lung disease/pneumothorax/lung metastasis/miliary TB
•8.Patients with fluid overload due to chronic kidney disease
•9.Patients with acute myocardial infarction
•10.Patients with do-not-intubate order
•11.Patients with home NIV support
•12.Pregnant patients

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