Stress and Marijuana Cue-elicited Craving and Reactivity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 87
- 试验地点
- 2
- 主要终点
- Subjective Craving of Marijuana
研究概览
简要总结
The purpose of this study is to explore the interaction between stress and marijuana cues, in hopes that it may lead to the development of new treatments for marijuana dependence.
详细描述
Although use of marijuana is widespread, little research has focused on the treatment of marijuana use disorders or on predictors of relapse. Although several factors contributing to relapse have been explored in other dependencies (i.e., alcohol, cocaine), little research has focused on drug cue-related or stress-induced relapse in marijuana-dependent individuals. Cue reactivity is a construct measured in a laboratory procedure where an individual's subjective, behavioral, and physiological responses are assessed following exposure to drug-related environmental cues or stressors. Investigating the effects of drug-related environmental cues and stress in marijuana-dependent individuals will be useful in guiding treatment development.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets Diagnostic and Statistical Methods (DSM)-IV Criteria for Marijuana Dependence
- •Between the ages of 18 and 65
- •Must abstain from marijuana use the day of testing and other drug use three days prior to testing
排除标准
- •Must not be taking any psychoactive medication, or medication that alters the hypothalamic pituitary adrenal (HPA) Axis functioning
- •Must not be taking any medications that alter heart rate or skin conductance monitoring
- •Cannot meet criteria for current major Axis I disorder (may alter response to stress)
- •Cannot be morbidly obese (Body Mass Index >39)
- •Cannot meet current abuse or dependence criteria of other substances in past 90 days
- •Must not have a medical condition that impacts HPA functioning (Hypertension, chronic pain, Addison's disease)
结局指标
主要结局
Subjective Craving of Marijuana
时间窗: approx 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues).
Defined as the score on the Marijuana Craving Questionnaire (MCQ), range 7-84, higher scores indicate more craving
次要结局
- Physiological Assessments: Serum Cortisol, ACTH, BP, HR, and GSR(~ 2.5 hours (before, during and after exposure to stressor condition as well as exposure to neutral and marijuana-associated cues).)
- Feelings of Stress/Anxiety as Measured by the State-Trait Inventory (STAI)(~2 hours)
- Current Mood as Assessed by the Mood Form(~2 hours)
研究者
Aimee McRae-Clark
Associate Professor of Psychiatry
Medical University of South Carolina