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临床试验/NCT00920348
NCT00920348Unknown不适用

The Canadian Cohort Obstructive Lung Disease

McGill University Health Centre/Research Institute of the McGill University Health Centre9 个研究点 分布在 1 个国家目标入组 1,500 人开始时间: 2010年1月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
1,500
试验地点
9
主要终点
What risk factors other than smoking determine the development and progression of COPD.

研究概览

简要总结

Abstract Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in Canada. COPD is not just a disease of men, nor is it solely a disease in old age. Women have been underrepresented and early disease has not been studied. Underdiagnosis of COPD remains a significant problem, and it may indicate an unmet healthcare need. This can potentially results not only in a patient been misinformed, but can lead to incorrect management.

Epidemiological research is needed to develop a framework to combat this major health problem, by better characterization of the population of men and women at risk and patients with early disease, by better understanding which factors modifiable through health interventions are related to health perception (health-related quality of life) and disease evolution.

This will be possible through a nationwide study, the Canadian Cohort Obstructive Lung disease (CanCOLD), a prospective longitudinal study. The CanCOLD study is built on the current ongoing prevalence nationwide study, the Canadian Obstructive Lung disease "COLD" study.

The CanCOLD will be the first study to assess prevalence of disease across Canada and its consequence in men and women, and to evaluate a conceptual model of disease severity based on patient's health perception (health-related quality of life). Ultimately, this project will extend to a longitudinal follow up (3 years or beyond) and will allow to have a better understanding of the lifestyle risk factors, not only smoking but also diet, physical activity, and co morbid conditions. This will be a great asset to shift from management of a single risk factor (tobacco control) to total COPD risk management. The results of the study will greatly help to assist decision makers in developing policies to improve the diagnosis, the management of COPD and to optimize health care services use.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
40 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All the subjects have taken part in the COLD study, a true population based prevalence study. Subjects must have an inclusion criteria of 40 years and older to participate in the COLD study.

排除标准

  • 未提供

结局指标

主要结局

What risk factors other than smoking determine the development and progression of COPD.

时间窗: One visit a year every 18 months

次要结局

  • What are the combinations of the disease and patient attributes that differentiate individuals (men/women) with COPD as they relate to relevant outcomes (symptoms, exacerbations, disease progression or death)(One visit a year 18 months)
  • Is early detection of COPD with spirometry meaningful according to sex and ageing.(One visit a year 18 months)

研究者

发起方
McGill University Health Centre/Research Institute of the McGill University Health Centre
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jean Bourbeau

MD, M.Sc.

McGill University Health Centre/Research Institute of the McGill University Health Centre

研究点 (9)

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