Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Association between PEEP and ICP
研究概览
简要总结
The purpose of this study is to collect physiologic data from patients with severe brain injury who require mechanical ventilation in order to describe the impact of ventilation, specifically positive end expiratory pressure (PEEP), on intracranial pressure (ICP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with severe brain injury (GCS 8 or less)
- •Receiving mechanical ventilation
- •Receiving intracranial pressure monitoring
排除标准
- •Esophageal varices
- •Esophageal trauma
- •Recent esophageal surgery
- •Coagulopathy (Platelets < 80k or INR> 2 )
- •Other contraindication for esophageal manometry
- •Already receiving PEEP > 15 cmH2O at enrollment
- •Intracranial hypertension (defined as ICP > 20 mmHg)
- •Decompressive hemi-craniectomy
研究组 & 干预措施
PEEP Titration Arm
PEEP titrated mechanical ventilation
干预措施: PEEP titrated mechanical ventilation (Other)
结局指标
主要结局
Association between PEEP and ICP
时间窗: Change from baseline to 20 minutes
Intracranial pressure will be measured and recorded using the existing intracranial pressure monitoring device placed previously as part of the patient's routine care. The association between positive end expiratory pressure and intracranial pressure will be analyzed as the primary outcome.
次要结局
- Association between transpulmonary pressure and ICP(Change from baseline to 20 minutes)
- Association between PEEP and cerebral hemodynamics(Change from baseline to 20 minutes)
研究者
Valerie Banner-Goodspeed
Clinical Research Administrator
Beth Israel Deaconess Medical Center