The Role of Compliance With Positive Airway Pressure Use on Blood Pressure in Patients With Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,168
- 试验地点
- 2
- 主要终点
- drop in blood pressure
研究概览
简要总结
The aim of the study was to determine the long term effects of compliance with positive airway pressure therapy on blood pressure in both hypertensive and normotensive patients with obstructive sleep apnoea hypopnoea syndrome.
详细描述
Scientific data about the causal role of obstructive sleep apnoea hypopnoea syndrome (OSAHS) in the development of systemic hypertension and the effects of positive airway pressure (PAP) treatment on blood pressure (BP) control are continuously increasing; however they are controversial. We aimed to determine the long term effects of compliance with PAP therapy on BP in both hypertensive and normotensive patients with OSAHS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •newly diagnosed OSAHS by polysomnography according to standard criteria
- •no history of previous PAP therapy
- •normotensive and hypertensive patients
- •an above-elementary school education.
排除标准
- •refusal to participate
- •refusal of PAP therapy
- •secondary hypertension
- •central sleep apnea syndromes
- •obesity hypoventilation syndrome
- •restrictive ventilator syndromes
- •history of established cardiovascular disease
- •severe congestive heart failure
- •a history of life-threatening arrhythmias
- •severe cardiomyopathy
- •significant chronic kidney disease
- •long-term oxygen therapy
- •family or personal history of mental illness
- •drug or alcohol abuse
- •severe cognitive impairment
- •concurrent oncological diseases
- •need for chronic use of medication that may affect BP levels
- •pregnancy
- •history of narcolepsy or restless leg syndrome
结局指标
主要结局
drop in blood pressure
时间窗: two years
次要结局
未报告次要终点
研究者
Izolde Bouloukaki
MD, PhD, Consultant at NHS
University of Crete