TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Cognitive improvement effects of WM training with active tDCS vs. sham
研究概览
简要总结
The overarching goals of this study are to employ cognitive testing to understand how transcranial direct current stimulation (tDCS), when used concurrently with cognitive training tasks, can affect cognitive impairment symptoms in individuals with long COVID, or post-acute sequelae SARS-CoV-2 infection (PASC), and to examine variability in response between active and sham tDCS treatment groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ability to provide consent and comply with study procedures
- •Age 18 to 60 years old
- •Estimated IQ within the specified range (70 <= IQ E <= 115)
- •Current post-acute sequelae SARS-CoV-2 infection (PASC) as defined by the National Center for Health Statistics post-COVID-19 conditions survey ((Long COVID 2022), including impaired cognition symptoms, for at least 3 months post-infection
- •Ability to participate in four weekly 40' training sessions over four weeks and participate in two assessments
- •English speaking
排除标准
- •Any medical condition or treatment with neurological sequelae (e.g. stroke, tumor, loss of consciousness >30 min, concussion involving hospital admission, HIV)
- •Contraindications for tDCS (e.g. history of seizures)
- •Five or more sessions of neuromodulation (such as tDCS) or cognitive training in the past 6 months
结局指标
主要结局
Cognitive improvement effects of WM training with active tDCS vs. sham
时间窗: baseline and post-test assessment, 4 weeks
shown by WM task progression and performance on cognitive testing measures
Generalization of cognitive effects of active tDCS vs. sham
时间窗: baseline and post-test assessment, 4 weeks
includes effect on PASC-related cognitive impairment symptoms
次要结局
未报告次要终点