Adding Insulin to IVF Culture Media Significantly Improve Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 360
- 试验地点
- 2
- 主要终点
- clinical Pregnancy rate ( % )
研究概览
简要总结
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
详细描述
The IVF culture media design and upgrade underwent many ideas during the last 3 decades, we suppose that adding insulin as a hormon and growth factor might improve embryo development in vitro so we decide to design a trial to compare the embryogenesis by sibling Oocytes of the same patient between to arm of the same culture media and yhe same culture condition but with one arm with insulin and the other is traditional one and closely monitor the outcome within the 2 arms abd record the results
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •normal responder
- •Tubal factor infertility
- •mild asthenozoospermia
排除标准
- •patient over 40
研究组 & 干预措施
In Vitro culture media with insulin
We will add insulin to the single step culture media to monitor the embryogenesis
干预措施: Adding insulin to In Vitro culture media (Other)
In Vitro culture media without insulin m
The embryos will be cultured in the media without insulin and compare this arm as the control arm with the interventional one.
结局指标
主要结局
clinical Pregnancy rate ( % )
时间窗: 6 months
次要结局
- Blastocyst rate ( % )(6 months)
- Blastocyst quality rate ( % )(6 months)
研究者
Muhammad Fawzy
IVF Laboratory Director
Ibn Sina Hospital