Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure Admitted in Liver Specialty ICU (Intensive Care Unit)- An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 522
- 试验地点
- 1
- 主要终点
- Mortality within 1 month during ICU (Intensive Care Unit) stay.
研究概览
简要总结
After successful screening diagnosis of cirrhosis and/or acute or chronic liver failure will be made. These patients will undergo detail clinical, biochemical and microbiological examination at baseline. Clinical examination and Biochemical evaluation will be done daily and signs of infection will be noted. Patients will undergo microbiological screening for infection every 48 hours. Patients suspected or diagnosed to be suffering from infections will be treated as per ILBS (Institute of Liver and Biliary Sciences) antibiotic policy. Site and etiology (bacterial and/or fungal) of infections will be noted in all patients at admission in liver specialty ICU (Intensive Care Unit) and during the ICU (Intensive Care Unit) stay. All the patients will be followed until discharge or death in ICU (Intensive Care Unit).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A clinical, radiological or histological diagnosis of cirrhosis and/or ACLF (Acute on Chronic Liver Failure).
- •Age > 18years
排除标准
- •Previous liver transplantation.
- •Patients who died within 8 hours of ICU (Intensive Care Unit) admission.
- •Acute liver failure
- •Lack of consent
- •Patient on steroids/ or any other immunosuppressive medication
结局指标
主要结局
Mortality within 1 month during ICU (Intensive Care Unit) stay.
时间窗: 30 days
次要结局
- Number of days stayed in ICU (Intensive Care Unit).(30 days)
- Proportion of patients with organ failure.(30 days)
- Risk factors determination in development of multidrug resistance bacteria.Risk factors are defined as Nosocomial infection,Recent Hospitalization, recent antibiotic usage, SBP (spontaneous bacterial peritonitis)prophylaxis, diabetes etc(30 days)
