临床试验/NCT04012632

NCT04012632已完成不适用

Polymorphisms in the Kisspeptin/GPR54 Pathway Genes and the Risk of Early Puberty

Shenzhen Center for Disease Control and Prevention0 个研究点目标入组 628 人开始时间: 2016年9月1日最近更新: 2019年7月11日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 628
主要终点: the polymorphism in the KISS1/GPR54 pathway genes

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Retrospective

入排标准

年龄范围: 7 Years 至 10 Years（Child）
性别: Female
接受健康志愿者: 是

入选标准

•Clinical diagnosis of central precocious puberty or early and fast puberty.

排除标准

•The participants who were not the first visit to the hospital and had been treated before.
•The participants who were with endocrine disorders.

结局指标

主要结局

the polymorphism in the KISS1/GPR54 pathway genes

时间窗: 3 months

functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.

次要结局

未报告次要终点

研究者

发起方

Shenzhen Center for Disease Control and Prevention

申办方类型

Other Gov

责任方

Principal Investigator

主要研究者

Di Li

Doctor

Shenzhen Center for Disease Control and Prevention

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