Efficacy of Individualized Homoeopathic Medicines in the Treatment of Hyperuricemia in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial

Hyperuricemia is defined as an elevated serum uric acid level usually above 360 μmol/l (6 mg/dL) for women and 420 μmol/l (7.0 mg/dL) for men. In a review on population-based prevalence, hyperuricemia was placed at the 13th position among 21 Global Burden of Diseases (GBD).The majority of those who have this disorder won’t show any overt symptoms, but it’s unknown how long-term hyperuricemia may affect renal function, general morbidity, and cardiovascular health in general. Conventionally, allopurinol has only been used to treat hyperuricemia; however, The most well-known side effect of allopurinol in dermatology is its severe cutaneous adverse responses. Homoeopathy is the second largest widely accepted therapeutic system of Medicine, may offer a better alternative in prevention and treatment hyperuricemia HU. Despite the abundance of successfully treated examples of hyperuricemia and gout in homoeopathy literature, high quality research evidence is still limited. Although many good qualities clinical trial have been published under the name of hyperuricemia in Homoeopathy. But most of the randomized, placebo-controlled trial done at 1:1 ratio. So, this trial is nothing but another attempt to detect and prove the efficacy of IHMs in reducing the serum uric acid levels (SUA) by 2:1 Randomized ratio. A double-blind, randomized (2:1), placebo-controlled trial will be conducted on 64 adults who are suffering from  HU at the outpatient’s department of D. N. De Homoeopathic Medical College and Hospital. Assessment will be done using SUA levels [Primary outcomes], Questionnaire assessing impact of hyperuricemia on quality of life (HUQoLQ) score and SF -36 (Short Form-36) [Secondary outcomes] every month up to 3 months. Comparative analysis will be carried out to detect group differences. Results will be published in scientific journals.