Imaging Prostatic Lipids to Distinguish Aggressive Prostate Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 2
- 主要终点
- Number of participants with increased intraprostatic lipid concentration
研究概览
简要总结
A prostate cancer diagnosis starts a list of events that often leads to fast-moving treatment, thought by many to result in vast over-treatment of this disease. So, discovery of different diagnostic methods that allow clinicians to identify slow-growing from potentially fast-growing disease prior to or at the time of prostate biopsy could result in early and suitable treatment for men at greatest risk, while greatly decreasing the number of biopsies, surgical procedures, hormonal and chemotherapeutic treatments, cost, and patient worry, for those with more slow-growing disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Prostate cancer diagnosis prior to treatment
- •Age 21 years or older
- •Signed informed subject consent
- •Prostatectomy as planned prostate cancer treatment
排除标准
- •Men who do not choose prostatectomy
- •Men who have undergone any neoadjuvant therapy
- •Men who have cardiac pacemakers or other implanted electronic devices
- •Men who have any surgically implanted metal
- •Men who have had any surgical procedure that precludes placement of endorectal probe
- •Indication of dementia or memory issues listed on problem list
- •Men who indicate exposure to ocular metal fragments; confirmed by positive ocular x-ray
- •Men who are taking newly-prescribed (within 6 months of enrollment) lipid control medications
结局指标
主要结局
Number of participants with increased intraprostatic lipid concentration
时间窗: Up to 3 years
Determine the correlation between the amount of intraprostatic lipid using 1H (proton) magnetic resonance spectroscopic imaging (MRSI) with an endorectal coil obtained prior to prostatectomy with fatty acid synthase protein expression measured in benign and cancer tissue from prostatectomy samples.
次要结局
- Number of participants with increased tumor aggressiveness(Up to 3 years)
研究者
Jackie Shannon
Principal Investigator
OHSU Knight Cancer Institute