Infusion Laboratory: Protocol 5 (Flupenthixol)
试验速览
- 阶段
- 1 期
- 试验地点
- 2
- 主要终点
- Clinical physiological response to cocaine challen
研究概览
简要总结
The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as physiological effects of cocaine. Taken together, these relatively D-1 selective agents can help determine the extent to which DA-1 binding affects the reinforcing effects of stimulants.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •M/F, ages 21-
- •Meet DSM-IV criteria for cocaine dependence. Agree to conditions of the study and sign informed consent.
排除标准
- •Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nuring women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical condtions that deem participation to be unsafe.
结局指标
主要结局
Clinical physiological response to cocaine challen
Degree of drug craving
History, incidence and amount of drug use
Type and severity of stimulant withdrawal symptoms
Characterization of study population
Frequency and intensity of drug use and sexual beh
Evidence of change in neurophysiology and brain ac
Evidence of change in subjective responses to coca
Degree to which study medication influences change
Population incidence of symptoms of depression, po
次要结局
未报告次要终点