Physiological Changes in Nasal Patency in Response to Changes in Posture, Temperature, Humidity and Nasal Patency Measured by Acoustic Rhinometry
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Changes in nasal patency
研究概览
简要总结
To study nasal physiologic responses to changes in posture, temperatures, humidity and nasal patency with acoustic rhinometry.
详细描述
The purpose of this study was to utilize acoustic rhinometry to assess changes in nasal patency after alterations in posture, unilateral mechanical obstruction, temperature, and humidity.
Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant.
Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 58 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers, 18-58 years old
排除标准
- •Any nasal symptoms in the last 3 weeks
- •Marked septal deviation/polyposis/infection
- •Any history of allergy, asthma or immunodeficiency
- •Any systemic condition or infection (e.g., hypertension/diabetes/heart, liver, thyroid or kidney disease
- •Any spine or neck condition that would not allow normal postures
- •Pregnancy
结局指标
主要结局
Changes in nasal patency
时间窗: 5-10 minutes
次要结局
- Nasal volume(5-10 minutes)