Changes in Renal Perfusion During Hemodialysis in Patients with End-stage Renal Disease: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 主要终点
- renal perfusion
研究概览
简要总结
Residual renal function (RRF) characteristically declines after patients with end-stage renal disease (ESRD) initiate dialysis. Although RRF preservation correlates with improved patient's quality of life and survival prospects, poor understanding of the pathophysiology underlying RRF decline limits protection strategies.
详细描述
Hemodialysis (HD) is the primary renal replacement therapy for patients with end-stage renal disease. However, residual renal function (RRF) characteristically declines after these individuals start dialysis. This loss of RRF not only impacts the adequacy of dialysis and control of complications but also affects the patient's quality of life and survival prospects. Due to a lack of clear understanding regarding the pathophysiology underlying this decline in RRF, no effective strategies exist for its preservation at present. The objective of this study is to explore the changes in renal perfusion during hemodialysis in patients with end-stage renal disease, and provide a new idea for protection of RRF. This study was an observational study, and no interventions were performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years;
- •Clinical diagnosis of end-stage renal disease requiring long-term hemodialysis treatment, with dialysis duration ≤ 3 months;
- •Urine output > 500ml/day or GFR > 3ml/min/1.72m2;
- •Signed and dated informed consented is obtained.
排除标准
- •Presence of vascular access dysfunction (blood flow rate < 180ml/min);
- •Severe heart failure;
- •Active infection;
- •Infectious disease;
- •Patients with severe anemia;
- •Patients with polycystic kidney disease;
- •Expected dialysis duration < 6 months;
- •Pregnancy or lactation women;
- •Patients who are participating in other clinical studies, or who have participated in other clinical studies within 3 months prior to enrollment;
- •Unwillingness to be followed up or poor adherence to treatment;
- •Other circumstances that the investigator considers unsuitable for enrolment.
结局指标
主要结局
renal perfusion
时间窗: one day
Changes in renal perfusion during hemodialysis in patients with end-stage renal disease
次要结局
- diastolic blood pressure(one day)
- systolic blood pressure(one day)
- urine volume(10 months)
研究者
Yuanjun Yang
Director
Chinese PLA General Hospital