A Multi-center, Open, Randomized, Parallel-group Study to Compare the Compliance of Patients Treated With Once-daily (od) or Twice-daily (Bid) Glimepiride and Metformin Fixed Combination Therapy
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- Handok Inc.
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- compliance of patients treated with once-daily or twice-daily
研究概览
简要总结
The study design of this trial is open-label, randomized, multi-center, parallel-group study.
详细描述
The effectiveness of treatment of a disease depends mainly on two factors: the efficacy of the treatment and the compliance of the patient with this treatment. Polymedication is one of the predisposing factors to low compliance in type 2 DM. It can be expected that a simple regimen may improve compliance. Amaryl Mex phase III trial was not designed to compare the compliance of patients with different dosing regimens of oral antidiabetic drugs. However, it was found that patients' compliance in the morning was better than in the evening, suggesting that Amaryl Mex once daily regimen may improve compliance. Pill count is the gold standard for measuring compliance, but this method provides incomplete and unreliable results. Advanced electronic monitoring device obtains details of patients' behavior during the day and over long periods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged between 18 ~ 75 years at screening
- •Patients who have been diagnosed with type 2 DM for at least 3 months
- •Patients who were treated with a stable dose with combination therapy of glimepiride 4mg or more and metformin 1000mg or more which can switch to Amaryl M 2/500mg bid or Amaryl Mex 2/500mg 2T od regimen.
- •HbA1c ≤ 9 % at randomization
- •BMI ≤ 40 kg/m2 at randomization
- •Patients who would give the informed consent
- •Patients who can perform SMBG and record the data on the patient's diary
- •Patients who can understand and use MEMS properly
排除标准
- •Patients with the medical history of acute metabolic complications such as diabetic ketoacidosis, hyperosmolar nonketotic coma within 3 months prior to the study participation
- •Patients who are under insulin therapy at randomization
- •Patients who received systemic corticosteroid agent within 4 weeks prior to the study participation
- •Patients with acute, severe cardiovascular disease (e.g., heart failure, myocardial infarction, stroke, etc).
- •Pregnant or lactating females
- •history of drug or alcohol abuse
- •Patients with known hypersensitivity to the ingredient of the study drug or drugs in sulfonylurea, sulfonamide, biguanide class
- •Night-shift workers
- •Patients with an experience of participating in other clinical trial within 3 months prior to the study participation
- •Clinically significant laboratory abnormality on screening labs or any medical condition that would affect the completion or outcome of the study based on investigator's decision
- •Patients with serum creatinine level > 1.5 mg/dl in male and > 1.4 mg/dl in female
- •Patients with ALT or AST > 3x ULN
- •Any conditions requiring help of others with drug administration (e.g. manual disability, serious visual defect, etc.)
研究组 & 干预措施
Amaryl MEX
干预措施: Glimepiride/ Metformin (Drug)
Amaryl M
干预措施: Glimepiride/ Metformin (Drug)
结局指标
主要结局
compliance of patients treated with once-daily or twice-daily
时间窗: 24 weeks
次要结局
- Blood glucose lowering effect(24 weeks)
- Episodes of hypoglycaemia(24 weeks)
- other adverse events(24 weeks)