Physical Exercise and Coronary Artery Plaque Composition
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Artery plaque composition evaluated by intravascular ultrasound and virtual histology
研究概览
简要总结
The purpose of this study is to examine the effect of two different physical exercise protocols on changes in coronary artery plaque composition and development of in-stent restenosis in patients treated with percutaneous coronary intervention with stent implantation. The investigators will compare aerobic interval training and moderate continuous training. Both exercise protocols have a duration of 12 weeks. The investigators hypothesize that aerobic interval training is superior to moderate continuous training regarding effects on the composition of coronary artery plaques and a reduction in the development of in-stent restenosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable or unstable coronary artery disease treated with percutaneous coronary intervention with stent implantation,
- •informed patient consent
排除标准
- •ST-elevation myocardial infarction,
- •inability to give informed consent,
- •inability to participate in regular training due to residency, work situation or comorbidity,
- •any known chronic inflammatory disease other than atherosclerosis,
- •planned surgery within the next four months
结局指标
主要结局
Artery plaque composition evaluated by intravascular ultrasound and virtual histology
时间窗: After 12 weeks
Findings at 12 weeks will be compared to baseline results
次要结局
- Occurrence of in-stent restenosis related to endothelial dysfunction, inflammatory biomarkers and the dimension of the main left coronary artery(After 12 weeks)
研究者
Rune Wiseth
Professor Rune Wiseth
Trondheim University Hospital