The Effects of Recurrent PE on Women and Offspring's Health
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- level of FT3,FT4, and hTSH in blood
研究概览
简要总结
The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.
详细描述
The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women with at least twice of delivery history
排除标准
- •women with chronic hypertension
结局指标
主要结局
level of FT3,FT4, and hTSH in blood
时间窗: 5 years after the second deliver
women
blood pressure and hypertension of women
时间窗: 5 years after the second deliver
blood pressure ≥140/90 mmHg
blood pressure and hypertension of offspring
时间窗: 5 years old
blood pressure≥140/90 mmHg
level of cholesterol, LDL, HDL, VLDL-C in blood
时间窗: 5 years after the second deliver
women
level of glycosylated hemoglobin in blood
时间窗: 5 years after the second deliver
women
level of AST and ALT in blood
时间窗: 5 years after the second deliver
women
次要结局
- BMI of offspring(5 years old)
- level of AI37℃、AI4℃、PRA、ALD、AngII in blood(5 years after the second deliver)
- level of fructosamine in blood(5 years after the second deliver)
- level of insulin in blood(5 years after the second deliver)
研究者
Dunjin Chen
Director
Guangzhou Medical University