Breath Carbon Monoxide Measurement Predicts Oxidative Stress Which Cause of Deteriorations of Lung Functions in Waterpipe Smokers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 主要终点
- Breath Carbon Monoxide Level
研究概览
简要总结
Waterpipe is a tool for smoking tobacco, which is thought to be less harmful than cigarette. Unfortunately, there aren't adequate studies about its harms to health that are threatening the young generation all over the world today. The objective of this study was to show the carbon monoxide (CO) levels in waterpipe smokers' breaths, whether can be used or not to reflect the changes of oxidative stress for this reason to predict harmful effects on the pulmonary functions.
详细描述
Waterpipe or hookah uses a different kind of tobacco, which is available in most Balkan countries, Middle East and South Asia. Popularity of smoking waterpipe among European, Canadian, and American young people has shown a dramatic rise over the past decade. The growing popularity of waterpipe use among U.S. teens and adults is evidenced by media reports and the recent rapid proliferation of waterpipe establishments (bars, cafes, or restaurants) in large cities and near college campuses. Typical waterpipes have the following components; a bowl where the tobacco is placed and heated, usually with burning embers or charcoal, a vase or smoke chamber which is partially filled with water, a pipe or stem connecting the bowl to the vase by a tube that carries the smoke down into the water, and a hose with a mouthpiece through which the smoke is drawn from the vase. As the smoker inhales, the tobacco smoke is sucked down from the bowl and then bubbles up through the water into the air of the smoke chamber and then through the hose to the smoker. At the end of a smoking session, the dirty water is thrown away and the waterpipe vase is refilled for the next user. Although each smoking session generally lasts about 45 to 60 minutes, it can also continue for several hours.
There is a misconception about smoking waterpipe that it is less harmful than cigarettes, and that's why smoking waterpipe is dramatically increasing especially among young people. While the adverse effects of smoking cigarette are widely described, there are just a few investigations about waterpipe and its effects. This study was designed to investigate the effects of smoking waterpipe on pulmonary functions and oxidative stress parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants who haven't determined major health problems,
- •between ages 18-40.
排除标准
- •Participants who under age 18 and above 40,
- •pregnant women,
- •individuals who have major health problems
结局指标
主要结局
Breath Carbon Monoxide Level
时间窗: Up to 4 months
Levels of CO in breath will be measured in either waterpipe smokers or control group.
次要结局
- Plasma TAS (Total Anti-Oxydant Status) Measurement.(Up to 4 months)
- A spirometric Test; FVC (Forced Vital Capacity) Measurement.(Up to 4 months)
- A spirometric Test; FEF25-75 (Forced Expiratory Flow in 25-75%) Measurement.(Up to 4 months)
- Plasma OSI Measurement.(Up to 4 months)
- A spirometric Test; FEV1/FVC (Forced Expiratory Volume in One Second/Forced Vital Capacity) Measurement.(Up to 4 months)
- Plasma ARES (Arylesterase) Measurement.(Up to 4 months)
- A spirometric Test; PEF (Peak Expiratory Flow) Measurement.(Up to 4 months)
- Plasma TOS (Total Oxydative Stress) Measurement.(Up to 4 months)
- A spirometric Test; FEV1 (Forced Expiratory Volume in One Second) Measurement.(Up to 4 months)
- Plasma sPON (Stimulated Paraoxonase) Measurement.(Up to 4 months)
- Plasma PON (Paraoxonase) Measurement.(Up to 4 months)
研究者
Mukremin Er
Mukremin Er, MD.
Ataturk Training and Research Hospital
