Low Tidal Volume for Lung Protection During Anesthesia of Laparoscopic Surgery in Trendlenburg Position
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- postoperative pulmonary complications
研究概览
简要总结
Mechanical ventilation of patients undergoing laparoscopic surgery may induce lung injury. Since lung protective ventilation has been recommended during anesthesia to prevent ongoing lung injury, so in our study the investigators will compare three different lung protective strategies regarding their lung protective effect measured by the incidence of postoperative pulmonary complications, perioperative oxygenation and postoperative inflammatory mediator release.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients undergoing laparoscopic colorectal or gynaecologic surgery with expected time more than two hours
排除标准
- •refusal, preoperative pulmonary disease
研究组 & 干预措施
Group 1
mechanical ventilation with Tidal volume 4 ml/kg and PEEP 8-10 cm H2o
干预措施: mechanical ventilation (Device)
Group2
mechanical ventilation with Tidal volume 6 ml/kg and PEEP 8-10 cm H2o
干预措施: mechanical ventilation (Device)
Group 3
mechanical ventilation with Tidal volume 8 ml/kg and PEEP 8-10 cm H2o
干预措施: mechanical ventilation (Device)
结局指标
主要结局
postoperative pulmonary complications
时间窗: 1 week
次要结局
未报告次要终点
研究者
AlRefaey Kandeel
Dr
Mansoura University