Cytokine-Induced Transcription in Depressed Inpatients Undergoing Psychotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 主要终点
- Change in depression
研究概览
简要总结
The goal of this observational study is to measure the levels of cytokine-induced transcription factor activation in a cohort of depressed inpatients undergoing psychotherapy. The study aims to answer the following main questions:
- Do psychological traits (i.e.: social inhibition, negative affectivity, ...) affect the activation of immunomodulatory transcription factors (STAT3, NFkB) in depressed patients?
- Are subjects with these psychological traits affected differently by psychotherapeutic intervention?
Study subjects are assessed for their psychological and behavioral traits and receive psychotherapeutic care over several weeks during hospital treatment. Peripheral blood mononuclear cells are isolated from the study subjects, and activation of transcription factors is measured by flow cytometry.
详细描述
Study subjects are assessed for their psychological and behavioral traits and receive psychotherapeutic care over several weeks during hospital treatment. Peripheral blood mononuclear cells are isolated from the study subjects, and activation of transcription factors is measured by flow cytometry.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of current depression
排除标准
- •inadequate knowledge of the German language
- •unable to give informed consent
- •severe psychiatric comorbidities, such as drug abuse and psychotic diseases
- •deemed critically unstable by their treating physician
结局指标
主要结局
Change in depression
时间窗: 6 weeks
Hospital Depression and Anxiety Scale (HADS). The HADS instrument is a 14-item scale, with seven items relating to anxiety and seven relating to depression item. Each item on qestionnaire is scored from 0-3 resulting in a score between 0 and 21 for either anxiety or depression with higher scores meaning a worse outcome.
次要结局
未报告次要终点
研究者
Prof. Thomas Meyer
Clinical Professor, Head of the Molecular Psychocardiology laboratory
University Medical Center Goettingen