Effect of Allopurinol Treatment on Insulin Resistance
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Change in insulin resistance (HOMA-IR)
研究概览
简要总结
Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin resistance of which is also named as prediabetes. With this background in mind, we aimed to test the effect of lowering serum uric acid level with allopurinol on insulin resistance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Serum uric acid level ≥7mg/dL
- •Glomerular filtration rate ≥60 ml/min
排除标准
- •presence of Diabetes Mellitus
- •history of gout
- •history of allopurinol use
- •body mass index ≥35 kg/m2
- •proteinuria ≥ 1gr/ day
- •presence of autoimmune disease
- •rheumatology associated disease
- •presence of hypothyroidism or hyperthyroidism
- •presence of diseases which may cause chronic inflammation or microalbuminuria (e.g. malignancy, chronic liver disease, hypertension, chronic lung disease)
研究组 & 干预措施
Uric acid ≥7 mg/dL
This arm will receive allopurinol treatment. 50 subjects will be recruited.
干预措施: allopurinol 300 mg./day (Drug)
Uric acid ≥6 and <7
This arm will not receive allopurinol. 50 subjects will be recruited.
干预措施: No intervention (Other)
Normouricemic
This arm is healthy controls. 30 subjects will be recruited.
干预措施: Normouricemic (Drug)
结局指标
主要结局
Change in insulin resistance (HOMA-IR)
时间窗: baseline and 3 months
次要结局
未报告次要终点
研究者
Mehmet Kanbay
Associate Professor Doctor Mehmet Kanbay
Istanbul Medeniyet University