Pilot randomised trial of functional imagery training plus treatment as usual versus treatment as usual alone to reduce alcohol-related harm in patients with alcohol-related liver disease admitted to hospital

niversity Hospitals Plymouth NHS Trust0 个研究点目标入组 54 人开始时间: 2021年3月12日最近更新: 2024年2月19日

适应症

试验速览

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35584873/ (added 20/05/2022) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38286518/ (added 09/02/2024)

•1. Adult patients >=18 years
•2. Able and willing to provide informed consent
•3. Clinical diagnosis of ArLD by at least one of the following methods
•3.1. Radiological appearance of fatty infiltration of the liver or cirrhosis
•3.2. Histological findings of cirrhosis or alcoholic steatohepatitis
•3.3. Signs consistent with chronic liver disease on physical examination
•4. High risk alcohol consumption (>50 units/week for males and >35 units/week for females) within 4 weeks prior to hospital admission
•5. AUDIT score >15 during current hospital admission
•6. Diagnosis of alcohol dependence as defined in ICD-10 meeting at least three of the following conditions:
•6.1. Strong desire or sense of compulsion to take alcohol
•6.2. Difficulties in controlling alcohol-consuming behaviour in terms of its onset, termination, or levels of use
•6.3. A physiological withdrawal state when alcohol use has ceased or been reduced, as evidenced by: the characteristic withdrawal syndrome; or use of alcohol with the intention of relieving or avoiding withdrawal symptoms
•6.4. Evidence of tolerance, such that increased doses of alcohol are required in order to achieve effects originally produced by lower doses
•6.5. Progressive neglect of alternative pleasures or interests because of alcohol use, increased amount of time necessary to obtain or consume alcohol or to recover from its effects
•6.6. Persisting with alcohol use despite clear evidence of overtly harmful consequences

•1. Any condition with an estimated life expectancy of less than 6 months
•2. Patients participating in concurrent interventional research
•3. Participants who have significant difficulties in adequate understanding of English such that they are unable to benefit from the trial intervention or sufficiently understand the trial documentation

发起方

niversity Hospitals Plymouth NHS Trust