NCT00520585Unknown不适用
Study of Influence of Atorvastatin on the Repolarisation Phase of Cardiomyocytes
适应症
相关药物
试验速览
- 阶段
- 不适用
研究概览
简要总结
The aim of this study is to evaluate influence of atorvastin on the repolarisation phase of cardiomyocytes. If there is any, it could be a part of positive "non-lipid" effect of statins in therapy of ischaemic heart disease.
Study hypothesis: atorvastin will decrease heterogeneity of repolarisation of cardiomyocytes in comparison with placebo
详细描述
The group will consist of 40 healthy volunteers. The study will be mono-centric. The repolarisation phase of cardiomyocytes will be evaluated using long - term 12-lead digital ECG monitoring. There will be 3 single ECG recordings - randomly after 20 mg of atorvastin, 80 mg of atorvastatin and placebo, respectively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •signed informed consent
- •age 18 - 45 years
排除标准
- •no chronic active disease
- •no concomitant pharmacotherapy, excluding hormonal contraception
- •abnormal ECG, echocardiography, laboratory findings
- •known hypersensitivity or myopathy due o statin
- •pregnancy, lactation, breast implants
- •skin disease
研究者
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